FTY720 (fingolimod) increases vascular tone and blood pressure in spontaneously hypertensive rats via inhibition of sphingosine kinase
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چکیده
منابع مشابه
FTY720 (fingolimod) sensitizes prostate cancer cells to radiotherapy by inhibition of sphingosine kinase-1.
Radiotherapy is widely used as a radical treatment for prostate cancer, but curative treatments are elusive for poorly differentiated tumors where survival is just 15% at 15 years. Dose escalation improves local response rates but is limited by tolerance in normal tissues. A sphingosine analogue, FTY720 (fingolimod), a drug currently in phase III studies for treatment of multiple sclerosis, has...
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Epoxyeicosatrienoic acids (EETs) are vasodilator, natriuretic, and antiinflammatory lipid mediators. Both cis- and trans-EETs are stored in phospholipids and in red blood cells (RBCs) in the circulation; the maximal velocity (V(max)) of trans-EET hydrolysis by soluble epoxide hydrolase (sEH) is threefold that of cis-EETs. Because RBCs of the spontaneously hypertensive rat (SHR) exhibit increase...
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The present study examines effects of administration of OKY 046, an inhibitor of thromboxane synthesis, for 100 days on systemic blood pressure and renal function in spontaneously hypertensive rats and in normotensive control rats. Untreated spontaneously hypertensive rats had higher values for thromboxane excretion in the urine and higher values for blood pressure than did normotensive control...
متن کاملVasopressin and Blood Pressure in Spontaneously Hypertensive Rats
In conscious, unrestrained spontaneously hypertensiTe rats (SHR), mean arterial blood pressure (MAP) increased from a pretreatment value of 150 ± 4 to 179 ± 7 mm Hg within 10 min (p < 0.01) following an intracerebroventricular (I.C.T.) Injection of captopril (2 mg/kg body weight), and the plasma vasopressin concentration was increased eightfold (p < 0.01). MAP then fell to 131 ± 5 mm Hg at 120 ...
متن کاملEffect of Cystamine on Blood Pressure and Vascular Characteristics in Spontaneously Hypertensive Rats
Background: Tissue transglutaminase (t-TG) has been implicated in small artery remodelling. The aim of this study was to determine if cystamine, an inhibitor of t-TG, could reduce blood pressure in spontaneously hypertensive rats (SHR) and if so to what extent this is mediated through small arteries. Methods: In vitro inhibition of t-TG, with cystamine, was studied in organ culture and wire myo...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 2012
ISSN: 0007-1188
DOI: 10.1111/j.1476-5381.2012.01865.x